Absolute Antibody specializes in recombinant antibody production, offering a wide range of sequence-defined antibodies for research, diagnostics, and therapeutic development. Their catalog includes antibodies in multiple engineered formats, such as humanized, species-switched, or isotype-switched variants, enabling greater flexibility in experimental design.
All antibodies are produced recombinantly, ensuring high purity, batch-to-batch consistency, and reproducible results. Widely used in flow cytometry, immunohistochemistry, ELISA and more, Absolute Antibody’s products support cutting-edge science across immunology, oncology, neuroscience, and beyond.
Product offering
Recombinant Antibodies
- Primary antibodies (sequence-defined, high purity)
- Research-grade biosimilars (e.g., Trastuzumab, Rituximab)
- Control antibodies (species/isotype-matched negatives)
- Antibodies for key targets in immunology, oncology, virology, and neuroscience
Engineered Formats
- Fc Silent™ antibodies (effector-null)
- AbFab2™ dimeric Fab fragments
- Prometheus™ humanized antibodies
- Bispecific and multispecific antibodies
- Isotype- and species-switched variants
Proteins & Reagents
- Recombinant proteins and Fc fusion reagents
- Synthetic multi-tag control proteins
- Free light chain standards (kappa/lambda)
Custom Services
- Antibody engineering (species switching, humanization, bispecifics)
- Hybridoma sequencing and rescue
Advantages of recombinant engineered antibodies over traditional monoclonal antibodies
- Defined recombinant antibody with known sequence and specificity for one target only
- More than 40% of all available monoclonals are not monospecific
- Spuriously expressed light chains in hybridomas may result in monoclonals with off-target specificities
- Availability of many different frameworks: different species, isotypes, subtypes, and even formats (scFv, Fab, bispecific)
- Using, e.g., rat monoclonals in mouse in vivo studies leads to antibody clearance by the immune system
- Can be expressed and purified in large quantities
Available formats
| Antibody format | Human | Mouse | Rat | Armenian hamster | Rabbit | Goat | Rhesus Macaque | Sheep |
|---|---|---|---|---|---|---|---|---|
| IgG | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| IgA | ✓ | ✓ | ||||||
| IgE | ✓ | ✓ | ||||||
| IgM | ✓ | ✓ | ✓ | |||||
| Fc domains | ✓ | ✓ | ||||||
| Fabs | ✓ | ✓ | ||||||
| Fab2 | ✓ | ✓ | ||||||
| Fc-fusions | ✓ | ✓ | ✓ | |||||
| Bispecifics | ✓ |
Case study: recombinant anti CD8 vs rat IgG anti CD8 in vivo
CD8+T-cell population in mice treated with anti-CD8 antibodies for depletion and isotype controls. Mouse IgG2a format is shown in purple and Rat IgG2b is shown in blue. Injections of 250 μg every 4 days. The recombinant anti CD8 antibody (mouse IgG2a) maintains T-cell depletion for over 60 days, whereas the rat IgG2B antibody loses efficacy after two weeks. Unpublished data, courtesy and property of the University of Basel, Switzerland.
Recombinant antibodies for immunotherapy research
- Your favourite research tools, now updated through antibody engineering for improved performance in vivo
- Reduce immunogenicity by matching antibody species to your host organism
- Tailor effector function by choosing from our range of antibody isotypes and subtypes
Re-engineered Fc Silent RPM1-14 anti PD1
Our re-enigeered anti PD1 antibody is derived from the rat IgG2a clone RMB1-14. The variable domains wer transferred into our proprietary Fc Silent syngenic mouse IgG2a framework in order to decrease immunogenicity and to increase bioavailability.
in a mouse HEP-16 liver cancer model, the re-engineered PD1 antibody showed a significantly higher potency with fewer injections needed, and an overall more robust treatment response than its conventional counterpart.
CONJUmAbs: High Purity, Carrier Free Biosimilar Antibodies
CONJUmAbs research-grade biosimilar antibodies from Absolute Antibody are carrier free products specifically designed for Antibody Drug Conjugate research. These concentrated, high-purity, and low endotoxin antibodies are formulated to make your conjugation procedure easier. Trastuzumab, Gemtuzumab, and Cetuximab can be purchased off-the-shelf, with other CONJUmAbs biosimilar antibodies available upon request.
- Concentrated – 5 mg/ml concentration eliminates the need to concentrate before conjugation
- High Purity – Additional purification step results in > 99% purity and > 98% monomer by SEC-HPLC
- Low Endotoxin – < 0.5 EU/mg endotoxin suitable for in vivo and in vitro use
- Carrier Free – Formulated without the use of Proclin 300, sodium azide, BSA, and other excipientsVisit our website to learn more and place your order.
Browse antibodies from Absolute Antibody
Antibody sequencing and engineering services
Absolute Antibody has developed a proprietary cloning system to enable rapid reformatting of antibodies into almost any format:
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