Cadherin-17 (CDH17), also known as liver-intestine cadherin (LI-Cadherin), is a cell adhesion protein predominantly expressed in normal intestinal epithelium and pancreatic ducts, as well as in gastrointestinal cancers such as gastric cancer (GC), colorectal cancer (CRC), and pancreatic adenocarcinoma (PDAC). High levels of Cadherin-17 have been linked to metastasis and poor prognosis. Cadherin-17 is considered as a target for diagnostics and therapeutics. arigo offers specific Cadherin-17 antibody [SQab30334] (ARG67064) to facilitate the detection of Cadherin-17.
Cadherin-17 and metastasis
Cadherin-17 plays a critical role in cancer metastasis, particularly in gastric, colorectal, liver, and breast cancers. In gastric cancer, Cadherin-17 induces lymphatic metastasis via NFkB pathway. In colorectal cancer, Cadherin-17 facilitates liver metastasis via α2β1 integrin-FAK axis. arigo offers a series of tools to accelerate the research of Cadherin-17 and metastasis.
| EMT Marker Antibody Panel (ARG30320) | Phospho-FAK Antibody Panel (ARG30203) | Phospho-NFkB Antibody Duo (ARG30248) |
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CDH17-targeting therapies
Cadherin-17 is a therapeutic target as it promotes cancer growth and metastasis. M13 phage display is a powerful tool for the development of therapeutic antibodies. Arigo offers the best M13 g8p antibody [SQab21250] (ARG66893) and Cadherin-17 protein to facilitate the development of CDH17-targeting therapies, as well as the kits to validate the cytotoxicity.
Histological markers of gastrointestinal cancer
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Arigo Biolaboratories - Antibodies, antibody duos, ELISA
Arigo Biolaboratories offers a broad and continuously expanding portfolio of antibody duos and antibody panels designed to support high-quality, reproducible research. Their range includes pathway duos, PTM duos, control duos, and ELISA duos, developed to meet diverse protein analysis needs.
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