Insulin resistance (IR) is a condition in which the target tissues loss the sensitivity to insulin, leading to impaired glucose disposal. Insulin resistance is a predominant risk factor linked to type 2 diabetes (T2D), nonalcoholic fatty liver disease (NAFLD), metabolic syndrome (MetS), and cardiovascular disease (CVD). Studies have shown that adipokine levels are highly associated with insulin resistance. arigo offers a multiplex ELISA kit to facilitate the quantification of IR-associated adipokine levels.
Human IR-associated Adipokine Multiplex ELISA Kit (ARG83643)
Benefits Concurrent measurement of 4 adipokines |
Adiponectin: 62.5 pg/mL |
Adiponectin | The most abundant adipokine, plays a vital role in glucose and fatty acid metabolism. It is a well-established biomarker of insulin resistance. Plasma adiponectin levels are inversely correlated with insulin resistance. |
Leptin | Primarily produced by adipose tissues, regulates appetite, energy expenditure, and glucose metabolism. Plasma leptin levels are directly correlated with insulin resistance. |
Resistin | Secreted by mononuclear cells and adipocytes, affects in glucose homeostasis and insulin resistance. Resistin levels are positively correlated with insulin resistance. |
IL-6 | Is a pleiotropic adipokine involved in regulation of inflammation, hematopoiesis, immune responses, and host defense. IL-6 leads to insulin resistance by impairing IRS-1 mediated insulin signaling. |
Insulin resistance pathway
IRS-1/Akt/GluT4 axis is widely used to examine insulin signaling and resistance. Adipokines mediate insulin resistance mostly through IRS-1/STAT3/SOCS signaling. arigo offers quality antibodies to facilitate the research of insulin resistance pathway.
IRS-1/Akt/GLUT4 Antibody ● IRS-1 pS636 ● Akt pS473 | p-IRS-1 Antibody Duo ● IRS-1 pS307 | JAK2-STAT3 Pathway Antibody ● JAK2 ● JAK2 pY1007/1008 |
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Arigo Biolaboratories - Antibodies, antibody duos, ELISA
Arigo Biolaboratories are dedicated to developing the most comprehensive collection of antibody duos and antibody panels
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