Aopia Bioscience is a cutting-edge biotechnology company founded in 2019 and based in North America specializing in automated isolation and purification of total extracellular vesicles (TEVs) from conditioned culture media or large volumes of biofluids. Their flagship NanoEX™ platform, powered by breakthrough hydrophilic Asymmetric Nanopore Membrane (ANM) and VanoFlow® cassette technologies, delivers fully enclosed processing with exceptional yield and purity, capable of processing up to 2L EV feed volume in about four hours while removing over 99% of free proteins. Designed for everything from R&D, pre-clinical use to large-scale therapeutic production, NanoEX™ offers researchers and manufacturers a scalable, affordable solution optimized for high purity TEV isolation and enrichment.
NanoEX™ automated bio-nanoparticle isolation platform
The NanoEX™ system from Aopia Biosciences, is a fully automated platform purpose-built for isolating extracellular vesicles (EVs), lipid nanoparticles (LNPs), gene therapy vectors, and other biological nanoparticles. It delivers unmatched yield and purity, achieving recovery rates of over 90% and removing more than 99.9 % of free proteins, all with less than five minutes of hands-on time.
Key Features
- Fully automated operation with under 5 minutes of hands-on time
- High-performance yields: > 90% recovery across EV, LNP, and viral vectors
- Superior purity: > 99.9% removal of free proteins
- Gentle processing to preserve structural and functional integrity of particles
- High scalability: handles sample inputs up to 2L for pilot and therapeutic workflows
- Enclosed single-use cassette format avoids cross-contamination. Cassette options support volumes from research to industrial scales.
VanoFlow® filtration cassettes
Key Features
- Fully enclosed
- No cleaning needed
- Up to 15 times enrichment
- Processing volume from 2 mL to 2 L
Cassette Name | SKU | Input Volume | Output Volume | Size Cutoff | Output EV Conc. | Reusability |
|---|---|---|---|---|---|---|
| VanoFlow-EXO-01 | VF-EXO-01 | 10 - 60 mL | ~4.5 mL | 30 nm | Up to 10^12/ml | Single Use |
| VanoFlow-EXO-10 | VF-EXO-10 | 50 - 300 mL | ~22 mL | 30 nm | Up to 10^12/ml | Reusable |
| VanoFlow-EXO-20 | VF-EXO-20 | 100 - 600 mL | ~35 mL | 30 nm | Up to 10^12/ml | Reusable |
| VanoFlow-EXO-40 | VF-EXO-40 | 0.2 - 1.2 L | ~65 mL | 30 nm | Up to 10^12/ml | Reusable |
| VanoFlow-EXO-60 | VF-EXO-60 | 0.3 - 2 L | ~90 mL | 30 nm | Up to 10^12/ml | Reusable |
