Advanced Targeting Systems, “the saporin people,” provides quality targeting reagents for molecular surgery: the specific elimination of cells to examine the impact on behavior and/or disease states. This product line includes targeted toxins and antibodies. Advanced Targeting Systems also has second conjugates that let researchers create their own specific targeting tools which are particularly useful in antibody screening for internalization. Flow cytometry and cell-based assay services are also available.
ZAP Secondary Conjugates
ZAP conjugates are non-targeted saporin conjugates that “piggyback” on to your primary targeting agent (biotinylated material or antibody).
ZAP Antibody Internalization Kit (for in vitro use)
The Antibody Z-kit contains a Secondary Antibody conjugated to Saporin (ZAP), Control Conjugate, plus all the components needed to screen your primary antibody for internalization.
| Target | Recommended Products | ||
|---|---|---|---|
| made with bivalent antibodies that recognize the whole IgG | made with monovalent (Fab) antibodies that recognize the whole IgG, without bivalent capping | made with monovalent (Fab) antibodies that recognize Fc region only | |
| alpaca/llama IgG (VHH domain) | Alpaca-ZAP (IT-87, KIT-87) | ||
| chicken IgY | Chick-ZAP (IT-62, KIT-62) | ||
| goat IgG | Goat-ZAP (IT-36, KIT-36) | ||
| guinea pig IgG | gPIG-ZAP (IT-64, KIT-64) | ||
| human IgG | Hum-ZAP (IT-22, KIT-22) | Fab-ZAP human (IT-51, KIT-51) | FabFc-ZAP human (IT-65, KIT-65) |
| human IgM | Hug-M-ZAP (IT-43, KIT-43) | FabFc-ZAP Hug-M (IT-78, KIT-78) | |
| mouse IgG | Mab-ZAP (IT-04, KIT-04) | Fab-ZAP mouse (IT-48, KIT-48) | FabFc-ZAP mouse (IT-89, KIT-89) |
| mouse IgM | Anti-M-ZAP (IT-30, KIT-30) | ||
| rabbit IgG | Rab-ZAP (IT-05, KIT-05) | Fab-ZAP rabbit (IT-57, KIT-57) | |
| rat IgG | Rat-ZAP (IT-26, KIT-26) | Fab-ZAP rat (IT-55, KIT-55) | FabFc-ZAP rat (IT-88, KIT-88) |
Antibody Internalization Kit
Screen antibodies for their ability to bind and internalize into your cells of interest using the ZAP Antibody Internalization Kit from Advanced Targeting Systems (ATS). Identify the most specific antibody for drug development or its use in an ADC (Antibody-Drug Conjugate).
The video will introduce you to the ZAP kit and walk you through the steps to complete a cytotoxicity assay.
Video available in multiple languages:
English • French • German • Italian • Japanese • Korean • Mandarin • Spanish
Downloads
| Filename | Download |
|---|---|
| ATS Catalogue 2021 |  |
