The Human Protein Atlas program and SARS-CoV-2 related proteins
When? Thursday, June 11th 2020, 4:00 PM - 5:00 PM CEST
Speaker: Cecilia Lindskog, PhD, Director of the Human Protein Tissue Atlas, Uppsala University, Sweden.
Please note that the number of "seats" is limited.
Abstract
The novel SARS-coronavirus 2 (SARS-CoV-2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS-CoV-2 infection, it is necessary to study the cell type-specific expression of proteins interacting with SARS-CoV-2. The Human Protein Atlas program has the overall aim to map all human proteins based on different omics technologies. The open-access database www.proteinatlas.org lists more than 300 proteins that are suggested to interact with SARS-CoV-2, and provide detailed information on their expression on a tissue, cellular and subcellular level. An extended analysis has been performed on Angiotensin I converting enzyme 2 (ACE2), suggested to be the key protein involved in SARS-CoV-2 host cell entry. In this webinar, we present the cell type-specific expression of ACE2 across 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results are compared with different datasets both on the mRNA and protein level. We also discuss the importance of integration of transcriptomics and antibody-based proteomics in studies on SARS-CoV-2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.