Swift Biosciences - Transforming NGS library preparation

About Swift Biosciences

Swift Biosciences is an innovative biotechnology company focused on creating tools for library preparation in the DNA sequencing sciences (NGS, PCR). Their products are designed to help customers analyze challenging samples that are often associated with translational work, including circulating, cell-free DNA and formalin-fixed, paraffin-embedded samples. Swift Biosciences has developed unique intellectual property in the fields of ligation, amplification, purification, and DNA repair. For example, their amplification technology was developed for use with fragmented DNA isolated from samples, such as FFPE and cfDNA, and enables the design of overlapping amplicons, offering full gene coverage. The tools developed in their efforts are directly applicable to research in agrigenomics, biotechnology, metagenomics, and the pharmaceutical industry.

Applications

  • Amplicon sequencing (e.g. for oncology/liquid biopsy)
  • Bisulfite sequencing
  • Epigenetics & ChIP-Seq
  • Circulating, cell-free DNA
  • FFPE isolated DNA
  • Hybridization capture sequencing
  • Metagenomics
  • Molecular identifiers
  • Single-cell methylation sequencing
  • Whole genome sequencing

Product offering

  • DNA sequencing library kits and panels for

The kits are applicable across the three major NGS platforms: Illumina, Ion Torrent, and Pacific Biosciences. Swift also offers kits for the construction of targeted DNA sequencing libraries in a single tube, from minute amounts of DNA in less than 2 hours.

We would like to present some of their kits:

Accel-NGS® Methyl-Seq DNA Library Kit

For the preparation of bisulfite-converted libraries on Illumina® NGS platforms.

The Accel-NGS® Methyl-Seq DNA Library Kit maximizes DNA recovery of bisulfite-converted samples and constructs libraries that accurately represent sample base composition. 

  • High recovery of input DNA
  • Low bias library preparation
  • Simple, 2-hour protocol
  • Inputs from 100 pg to 100 ng
  • Minimal PCR cycles required
  • Reduced amplification errors

Swift’s Adaptase™ technology enables unbiased adapter attachment to single-stranded bisulfite-converted DNA and eliminates significant (up to 90%) library loss associated with workflows where the NGS library is constructed prior to bisulfite conversion. The template-independent adapter attachment also improves the uniformity of methylome coverage compared to methods that incorporate adapters by random priming of single-stranded DNA.

This kit can be used for applications including WGBS, RRBS, and hybridization capture with NimbleGen™ SeqCap™ Epi Enrichment System. The Accel-NGS® Methyl-Seq DNA Library Kit is also compatible with bisulfite-converted DNA samples enriched by ChIP or other methods as well as ancient DNA samples that may contain uracil nucleotides as a result of damage. Application note

    Swift 2S Turbo DNA Library Kits

    This is an easy-to-use NGS library prep kit for routine sequencing. It comes in two configurations: the 2S Turbo (for quick implementation of core applications) and the 2S Turbo Flexible (for a more expanded choice of applications, and compatibility with your choice of adapters and indices). Datasheet