Neuroinflammation

Neuroinflammation occurs within the central nervous system (CNS) as a result of infection, injury, autoimmune processes, or toxicity. Microglia, as the specialized resident macrophage cells in the CNS, play crucial roles in both the initiation and resolution of neuroinflammation. However, their impact on neurons is complex. Microglia demonstrate a phenotypic plasticity that is directly influenced by the regional brain microenvironment. Thus, the M1/M2 dichotomy labeling used to describe other macrophage activity is inadequate to reflect the true heterogeneity of the microglial population. It is known that in neurodegenerative disease the microglia may display a “disease-associated microglia signature” that involves expression of genes found in both M1 and M2 profiles. Therefore, though important for the initial response to neuronal insult, microglia often contribute to the neuronal loss characteristic of these diseases.

GeneTex is proud to offer an outstanding, well-cited Iba1 antibody (GTX101495) as an important addition to your reagent collection for microglia research. This antibody was validated in part through side-by-side comparison with other market-leading antibodies for western blot and immunohistochemistry (see below).

GeneTex's Iba1 antibody (GTX101495) has multiple references and is a polyclonal IgG (host: rabbit) with reactivity to human, mouse and rat. This antibody against Iba1 has been validated for WB, ICC/IF, IHC-P, IHC-Fr, FACS, IP, and IHC.

Neuroinflammation brochure

Application references for Iba1 antibody (GTX101495 )

Zhao Z et al. J Neuroimmune Pharmacol 2019 Neuroprotective Effects of Genistein in a SOD1-G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis.
Application : IHC-Fr
Reactivity : Mouse

Yang CH et al. J Virol 2019; 93 (11) A Novel Murine Model Expressing a Chimeric mSCARB2/hSCARB2 Receptor Is Highly Susceptible to Oral Infection with Clinical Isolates of Enterovirus 71.
Application : IHC-P
Reactivity : Human

Wang SW et al. Alzheimers Res Ther 2017; 9 (1):41 A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease.
Application : IHC-P
Reactivity : Mouse

Yang X et al. Mol Med Rep 2017; (Epub) Surfactant protein A is expressed in the central nervous system of rats with experimental autoimmune encephalomyelitis, and suppresses inflammation in human astrocytes and microglia.
Application : IHC-P
Reactivity : Rat

Liou AT et al. Sci Rep. 2016; 6 A new animal model containing human SCARB2 and lacking stat-1 is highly susceptible to EV71.
Application : WB, IHC
Reactivity : Mouse

Yang S et al. ACS Chem Neurosci 2016; 7 (4):505-18 A Novel Multifunctional Compound Camellikaempferoside B Decreases Aβ Production, Interferes with Aβ Aggregation, and Prohibits Aβ-Mediated Neurotoxicity and Neuroinflammation.
Application : WB, ICC/IF

Kuan YH et al. Neurobiol Dis 2015; 78:134-45 Targeting P(2)X(7) receptor for the treatment of central post-stroke pain in a rodent model.
Application : ICC/IF
Reactivity : Rat

Liao CC et al. J Virol 2014: Immunodeficient Mouse Models with Different Disease Profiles by in vivo Infection with the Same Clinical Isolate of Enterovirus 71.
Application : IHC-P
Reactivity : Mouse