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XBP1 Antibody
XBP1 Antibody (catalog# NBP1-77681)
Novus Biologicals announced today a new XBP1 Antibody (NBP1-77681) for use in immune response and endoplasmic reticulum stress research.
X-box binding protein 1 (XBP1) is a nuclear transcription factor which activates the unfolded protein response during endoplasmic reticulum stress response. Specifically, XBP-1 is upregulated during ER stress, and directly binds the unfolded protein response element to induce mis-folding of several downstream proteins.
XBP-1 is also essential for the growth and differentiation of hepatocyte and plasma cells, as well as some brain development and cognitive ability formation. It has been implicated in a wide range of disorders, including Alzheimer’s disease, major affective disorder type 7, Crohn’s disease and IBS.
Novus’ new XBP1 Antibody (NBP1-77681) has been validated for use in immunofluorescence staining of human and mouse samples. However, we also offer an Innovator’s Reward™ Program for testing in novel species and applications.
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Immunoshitochemistry stain in mouse bladder using XBP1 antibody with DAB visualization and ahematoxylin counterstain.
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Immunofluorescence stain in HeLa cells using XBP1antibody with a FITC (green) secondary. Nuclei and actin were counterstained with Dapi (blue) and Phalloidin (red).
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XBP1 In The News
1. Iwawaki T, et al. Function of yeast and amphioxus tRNA ligase in IRE1alpha-dependent XBP1 mRNA splicing.BiochemBiophys Res Commun, 2011 Oct 7. PMID 21924241.
2. Bae J, et al. Identification of novel myeloma-specific XBP1 peptides able to generate cytotoxic T lymphocytes: a potential therapeutic application in multiple myeloma.Leukemia, 2011 Oct. PMID 21660045.
3. Dong L, et al. Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress. Oncogene, 2011 Aug 25. PMID 21423203.
We are also offering other XBP1 antibodies and recombinant proteins, control lysates and RNAi as well asother ancillary reagents from Novus Biologicals.
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