IF Image of c-Myc

 

Spotlight on CASP8 and STAG2

Malignant melanoma, the most dangerous type of skin cancer, is estimated to affect roughly one in every 65 adults. Although it is typically preventable, the only treatment is surgical tumor excision. Unfortunately, it is often difficult to prevent the cancer from spreading due to melanoma's high malignancy rates.

Scientists at the University of Leeds recently found that a DNA defect in the apoptosis mediator gene CASP8 significantly increases the risk of melanoma [PMID: 21983787]. Additionally, researchers at the Georgetown University School of Medicine discovered that one fifth of melanomas have a defective copy of the STAG2 Gene, which plays a role in the division of genetic material between cells. [PMID: 2021852505]. These exciting new discoveries offer promise for potential future treatments, and open important new avenues for melanoma research.

Here at Novus Biologicals we offer a number of CASP8 and STAG2 Antibodies, a few of which can be found below:

 

Caspase 8 Antibody
Rabbit Polyclonal
Catalog # NB600-576
Reacts with: Bv, Hu, Mu, Rt, Mk
Works In: IHC-P, IP, WB

STAG2 Antibody
Goat Polyclonal
Catalog # NB100-300
Reacts with: Hu, Xp
Works In: ICC, WB

IHC Image of Caspase 8

WB Image of STAG2

Formalin-fixed, paraffin-embedded human stomach stained with Caspase 8.

Nuclear extract from ~500,000 HeLa cells. Antibody: Affinity purified goat anti-SA2 used at 0.5 mcg/ml. Detection: Chemiluminescence with 15 sec. exposure.

New Cancer Antibodies

Laminin Protein
Catalog # NBP1-78301
Reacts with: Mu
Works In: Func, TCS

Survivin Antibody
Mouse Monolconal
Catalog # NB500-644
Reacts with: Hu, Rt
Works In: ICC, IF, IHC-P

IF Image of Laminin

ICC Image of Survivin

Schwann cells on Laminin-1 substratum

Survivin 8E2 antibody was tested in HeLa cells with FITC (green). Nuclei were counterstained with Dapi (blue).